If you are aspiring for admission to FIRST YEAR of any course in any college of this Univeristy then you can apply online.
The students from other states than Maharashtra can also apply without a need to travel initially only for purchasing brochures, application forms etc.
Exceptions are the courses for which centralised admissions are done by Govt. For the centralized admission process of the certain courses (such as BE, BTech, BArch, BEd, BPharm, MBA etc.) you will have to apply separately through the centralized admission procedure.